RNA-binding Proteins Part C

David Christianson · Karen N. Allen · Subashchandrabose Chinnathambi

сак 2027 · Methods in Enzymology Кніга 745 · Academic Press

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This volume of Methods in Enzymology presents a practical and multidisciplinary collection of contemporary methods for investigating RNA biology, RNA-binding proteins (RBPs), RNA–protein interactions, ribonucleoprotein (RNP) complexes, biomolecular condensates, liquid–liquid phase separation, RNA processing, translation, and RNA-mediated regulation. The chapters integrate complementary experimental and computational approaches, including biochemical reconstitution, quantitative microscopy, transcriptomics, proteomics, interactomics, NMR spectroscopy, structural biology, computational analysis, and tissue-based techniques.Together, these methods provide a versatile framework for elucidating how RNA and RBPs regulate cellular organization, gene expression, RNA metabolism, RNA processing, translation, and biomolecular phase behavior. Particular emphasis is placed on emerging applications in disease-associated molecular pathways, including neurodegeneration and neurological disorders, with coverage of topics relevant to Alzheimer's disease, Tau biology, and HIV-associated neurocognitive disorders. This volume provides researchers with practical methodological strategies for dissecting RNA–protein interactions and defining RBP function across molecular, cellular, and disease contexts. The collection is designed to serve as a valuable methodological resource for researchers investigating the mechanisms by which RNA–protein networks govern cellular processes and contribute to human disease. - RNA biology and RNA-binding proteins (RBPs) - RNA–protein interactions - Biomolecular condensates - RNA-dependent liquid–liquid phase separation (LLPS) - RNA processing, ribosome-associated complexes, and RNA regulation in health and disease

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After completing studies for the A.B., A.M., and Ph.D. degrees in chemistry at Harvard University, David W. Christianson joined the faculty of the University of Pennsylvania, where he is currently the Roy and Diana Vagelos Professor in Chemistry and Chemical Biology. At Penn, Christianson’s research focuses on the structural and chemical biology of the zinc-dependent histone deacetylases as well as enzymes of terpene biosynthesis. His research accomplishments have been recognized by several awards, including the Pfizer Award in Enzyme Chemistry and the Repligen Award in Chemistry of Biological Processes from the American Chemical Society, a Guggenheim Fellowship, and the Elizabeth S. and Richard M. Cashin Fellowship from the Radcliffe Institute for Advanced Study at Harvard University. Christianson is also a dedicated classroom teacher, and his accomplishments in this regard have been recognized by the Lindback Award for Distinguished Teaching at Penn and a Rhodes Trust Inspirational Educator Award from Oxford University. Christianson has also held visiting professorships in the Department of Biochemistry at Cambridge University and the Department of Chemistry and Chemical Biology at Harvard University. Christianson has served with Prof. Anna Pyle as Co-Editor-in-Chief of Methods in Enzymology since 2015.

Dr. Karen N. Allen works at the Department of Chemistry of the Boston University, the Metcalf Center for Science and Engineering

Subashchandrabose Chinnathambi is Additional Professor at the Department of Neurochemistry, National Institute of Mental Health and Neurosciences Hospital Bangalore, Karnataka, India. His scientific interests include physiopathology of neurodegenerative disorders, Tau Cytoskeleton, Tau-GPCR, purinergic and chemokine receptors, Tau stem cells, animal models, neuropharmacology, therapeutic approaches targeting Tau oligomers, and biomarkers for neurodegeneration. He serves on the editorial board for various international cell biology journals and is also a regular invited speaker at a number of meetings and workshops. Dr. Chinnathambi has more than 16 years of research experience in the area of neuroscience and Tau-related research in Alzheimer’s Disease.

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